Fe-MIL-101 exhibits selective cytotoxicity and inhibition of angiogenesis in ovarian cancer cells via downregulation of MMP.
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ABSTRACT: Though metal-organic frameworks (MOFs) have inspired potential applications in biomedicine, cytotoxicity studies of MOFs have been relatively rare. Here we demonstrate for the first time that an easily available MOF, Fe-MIL-101, possesses intrinsic activity against human SKOV3 ovarian cancer cells and suppress the proliferation of SKOV3 cells (IC50?=?23.6 ?g mL(-1)) and normal mouse embryonic fibroblasts (BABL-3T3, IC50?=?78.3??g mL(-1)) cells. It was more effective against SKOV3 cells than typical anticancer drugs such as artesunate (ART, IC50?=?96.9??g mL(-1)) and oxaliplatin (OXA, IC50?=?64.4??g mL(-1)), but had less effect on normal BABL-3T3 cells compared with ART (IC50?=?36.6??g mL(-1)) and OXA (IC50?=?13.8??g mL(-1)). Fe-MIL-101 induced apoptosis of human umbilical vein endothelial cells (HUVECs) via G0/G1 cell cycle arrest and decreased the mitochondrial membrane potential in HUVECs and induced apoptosis. Furthermore, Fe-MIL-101 exhibited stronger antiangiogenic effects in HUVEC cells than antiangiogenic inhibitor (SU5416) via downregulation the expression of MMP-2/9. Our results reveal a new role of Fe-MIL-101 as a novel, non-toxic anti-angiogenic agent that restricted ovarian tumour growth. These findings could open a new avenue of using MOFs as potential therapeutics in angiogenesis-dependent diseases, including ovarian cancer.
SUBMITTER: Wang J
PROVIDER: S-EPMC4870622 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
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