Ontology highlight
ABSTRACT:
SUBMITTER: Christo S
PROVIDER: S-EPMC4870632 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Christo Susan S Bachhuka Akash A Diener Kerrilyn R KR Vasilev Krasimir K Hayball John D JD
Scientific reports 20160518
Implantable devices have become an established part of medical practice. However, often a negative inflammatory host response can impede the integration and functionality of the device. In this paper, we interrogate the role of surface nanotopography and chemistry on the potential molecular role of the inflammasome in controlling macrophage responses. To achieve this goal we engineered model substrata having precisely controlled nanotopography of predetermined height and tailored outermost surfa ...[more]