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Interleukin-10 Family and Tuberculosis: An Old Story Renewed.


ABSTRACT: The interleukin-10 (IL-10) family of cytokines consists of six immune mediators, namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for the regulation of host defense against Mycobacterium tuberculosis infections. Specifically, IL-10 and IL-26 can suppress the antimycobacterial immunity and promote the survival of pathogen, while IL-22 and IL-24 can generate protective responses and inhibit the intracellular growth of pathogen. Knowledge about the new players in tuberculosis immunology, namely IL-10 family, can inform novel immunity-based countermeasures and host directed therapies against tuberculosis.

SUBMITTER: Abdalla AE 

PROVIDER: S-EPMC4870714 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Interleukin-10 Family and Tuberculosis: An Old Story Renewed.

Abdalla Abualgasim Elgaili AE   Lambert Nzungize N   Duan Xiangke X   Xie Jianping J  

International journal of biological sciences 20160427 6


The interleukin-10 (IL-10) family of cytokines consists of six immune mediators, namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for the regulation of host defense against Mycobacterium tuberculosis infections. Specifically, IL-10 and IL-26 can suppress the antimycobacterial immunity and promote the survival of pathogen, while IL-22 and IL-24 can generate protective responses and inhibit the intracellular growth of pathogen. Knowledge about the new  ...[more]

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