Ontology highlight
ABSTRACT:
SUBMITTER: Teratake Y
PROVIDER: S-EPMC4872541 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Scientific reports 20160519
The Nczf gene has been identified as one of Ncx target genes and encodes a novel KRAB zinc-finger protein, which functions as a sequence specific transcriptional repressor. In order to elucidate Nczf functions, we generated Nczf knockout (Nczf-/-) mice. Nczf-/- mice died around embryonic day 8.5 (E8.5) with small body size and impairment of axial rotation. Histopathological analysis revealed that the cell number decreased and pyknotic cells were occasionally observed. We examined the expression ...[more]