Down-regulation of C12orf59 is associated with a poor prognosis and VHL mutations in renal cell carcinoma.
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ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC4872751 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Down-regulation of C12orf59 is associated with a poor prognosis and VHL mutations in renal cell carcinoma.
Xie Jun J Zhu Chuangzhi C Wu Jianting J Li Cailing C Luo Liya L Xia Lingling L Li Xianxin X Gui Yaoting Y Cai Zhiming Z Li Zesong Z
Oncotarget 20160201 6
C12orf59 is newly identified gene in kidney. However, the relation of C12orf59 expression and clinic features is unknown. Here, our study showed that C12orf59 was broadly expressed in normal human tissues with high expression levels in kidney while its expression is beyond detectable in a panel of cancer cell lines. C12orf59 expression in RCC was significantly decreased compared with corresponding adjacent noncancerous tissues (P < 0.01). The decreased C12orf59 expression was correlated with lym ...[more]
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