Dataset Information

Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.

ABSTRACT: This study aimed to determine the serum levels of free L-carnitine, acetyl-L-carnitine and 34 acyl-L-carnitine in healthy subjects and in patients with or at risk of Alzheimer's disease. Twenty-nine patients with probable Alzheimer's disease, 18 with mild cognitive impairment of the amnestic type, 24 with subjective memory complaint and 46 healthy subjects were enrolled in the study, and the levels of carnitine and acyl-carnitines were measured by tandem mass spectrometry. The concentrations of acetyl-L-carnitine progressively decreased passing from healthy subjects group (mean±SD, 5.6±1.3 ?mol/L) to subjective memory complaint (4.3±0.9 ?mol/L), mild cognitive impairment (4.0±0.53 ?mol/L), up to Alzheimer's disease (3.5±0.6 ?mol/L) group (p<0.001). The differences were significant for the comparisons: healthy subjects vs. subjective memory complaint, mild cognitive impairment or Alzheimer's disease group; and subjective memory complaint vs. Alzheimer's disease group. Other acyl-carnitines, such as malonyl-, 3-hydroxyisovaleryl-, hexenoyl-, decanoyl-, dodecanoyl-, dodecenoyl-, myristoyl-, tetradecenoyl-, hexadecenoyl-, stearoyl-, oleyl- and linoleyl-L-carnitine, showed a similar decreasing trend, passing from healthy subjects to patients at risk of or with Alzheimer's disease. These results suggest that serum acetyl-L-carnitine and other acyl-L-carnitine levels decrease along the continuum from healthy subjects to subjective memory complaint and mild cognitive impairment subjects, up to patients with Alzheimer's disease, and that the metabolism of some acyl-carnitines is finely connected among them. These findings also suggest that the serum levels of acetyl-L-carnitine and other acyl-L-carnitines could help to identify the patients before the phenotype conversion to Alzheimer's disease and the patients who would benefit from the treatment with acetyl-L-carnitine. However, further validation on a larger number of samples in a longitudinal study is needed before application to clinical practice.

SUBMITTER: Cristofano A

PROVIDER: S-EPMC4873244 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.

Cristofano Adriana A Sapere Nadia N La Marca Giancarlo G Angiolillo Antonella A Vitale Michela M Corbi Graziamaria G Scapagnini Giovanni G Intrieri Mariano M Russo Claudio C Corso Gaetano G Di Costanzo Alfonso A

PloS one 20160519 5

This study aimed to determine the serum levels of free L-carnitine, acetyl-L-carnitine and 34 acyl-L-carnitine in healthy subjects and in patients with or at risk of Alzheimer's disease. Twenty-nine patients with probable Alzheimer's disease, 18 with mild cognitive impairment of the amnestic type, 24 with subjective memory complaint and 46 healthy subjects were enrolled in the study, and the levels of carnitine and acyl-carnitines were measured by tandem mass spectrometry. The concentrations of ...[more]

PMID: 27196316

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Dataset Information

Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.

Publications

Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.

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