Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC4873394 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Journal of computational chemistry 20160324 17
Transcription factors (TFs) are the proteins involved in the transcription process, ensuring the correct expression of specific genes. Numerous diseases arise from the dysfunction of specific TFs. In fact, over 30 TFs have been identified as therapeutic targets of about 9% of the approved drugs. In this study, we created a structural database of small molecule-transcription factor (SM-TF) complexes, available online at http://zoulab.dalton.missouri.edu/SM-TF. The 3D structures of the co-bound sm ...[more]