Ontology highlight
ABSTRACT:
SUBMITTER: Maldifassi MC
PROVIDER: S-EPMC4873749 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Maldifassi Maria C MC Baur Roland R Pierce David D Nourmahnad Anahita A Forman Stuart A SA Sigel Erwin E
Scientific reports 20160520
GABAA receptors are the main inhibitory neurotransmitter receptors in the brain and are targets for numerous clinically important drugs such as benzodiazepines, anxiolytics and anesthetics. We previously identified novel ligands of the classical benzodiazepine binding pocket in α1β2γ2 GABAA receptors using an experiment-guided virtual screening (EGVS) method. This screen also identified novel ligands for intramembrane low affinity diazepam site(s). In the current study we have further characteri ...[more]