Ontology highlight
ABSTRACT:
SUBMITTER: Jin R
PROVIDER: S-EPMC6725607 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Jin Rongsheng R Clark Suzanne S Weeks Autumn M AM Dudman Joshua T JT Gouaux Eric E Partin Kathryn M KM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050901 39
Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA, kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor currents relieve cognitive deficits caused by neurodegenerative diseases such as Alzheimer's disease and show promise in the treatment of depression. Previously, there has been limited understanding of the molecular mechanism of action for AMPA receptor potentiators. Here we present cocrystal structures of the glutamate recep ...[more]