Ontology highlight
ABSTRACT:
SUBMITTER: Miao H
PROVIDER: S-EPMC4873969 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Miao Hongming H Ou Juanjuan J Peng Yuan Y Zhang Xuan X Chen Yujuan Y Hao Lijun L Xie Ganfeng G Wang Zhe Z Pang Xueli X Ruan Zhihua Z Li Jianjun J Yu Liqing L Xue Bingzhong B Shi Hang H Shi Chunmeng C Liang Houjie H
Nature communications 20160518
Metabolic reprogramming in stromal cells plays an essential role in regulating tumour growth. The metabolic activities of tumour-associated macrophages (TAMs) in colorectal cancer (CRC) are incompletely characterized. Here, we identify TAM-derived factors and their roles in the development of CRC. We demonstrate that ABHD5, a lipolytic co-activator, is ectopically expressed in CRC-associated macrophages. We demonstrate in vitro and in mouse models that macrophage ABHD5 potentiates growth of CRC ...[more]