Ontology highlight
ABSTRACT:
SUBMITTER: Elbediwy A
PROVIDER: S-EPMC4874484 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Elbediwy Ahmed A Vincent-Mistiaen Zoé I ZI Spencer-Dene Bradley B Stone Richard K RK Boeing Stefan S Wculek Stefanie K SK Cordero Julia J Tan Ee H EH Ridgway Rachel R Brunton Val G VG Sahai Erik E Gerhardt Holger H Behrens Axel A Malanchi Ilaria I Sansom Owen J OJ Thompson Barry J BJ
Development (Cambridge, England) 20160317 10
The skin is a squamous epithelium that is continuously renewed by a population of basal layer stem/progenitor cells and can heal wounds. Here, we show that the transcription regulators YAP and TAZ localise to the nucleus in the basal layer of skin and are elevated upon wound healing. Skin-specific deletion of both YAP and TAZ in adult mice slows proliferation of basal layer cells, leads to hair loss and impairs regeneration after wounding. Contact with the basal extracellular matrix and conseque ...[more]