Ontology highlight
ABSTRACT:
SUBMITTER: Tang Y
PROVIDER: S-EPMC3736823 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Developmental cell 20130516 4
In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which the SSC-ECM interface is regulated and the outcome of such interactions on stem cell fate in vivo remain unknown. Here we demonstrate that conditional deletion of the membrane-anchored metalloproteinase MT1-MMP (Mmp14) in mesenchymal progenitors, but not in committed osteoblasts, redirects SSC fate decisions from ...[more]