The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.
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ABSTRACT:
SUBMITTER: Verma SK
PROVIDER: S-EPMC4875310 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.
Verma Sunil K SK Ganesan Trivadi S TS Kishore Uday U Parker Peter J PJ
Protein & cell 20110301 3
Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the ...[more]
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