Ontology highlight
ABSTRACT:
SUBMITTER: Ye H
PROVIDER: S-EPMC4875411 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ye Hao H Tang Kailin K Yang Linlin L Cao Zhiwei Z Li Yixue Y
Protein & cell 20120201 2
Drugs sharing similar therapeutic function may not bind to the same group of targets. However, their targets may be involved in similar pathway profiles which are associated with certain pathological process. In this study, pathway fingerprint was introduced to indicate the profile of significant pathways being influenced by the targets of drugs. Then drug-drug network was further constructed based on significant similarity of pathway fingerprints. In this way, the functions of a drug may be hin ...[more]