Ontology highlight
ABSTRACT:
SUBMITTER: Chang YC
PROVIDER: S-EPMC4875499 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Protein & cell 20130313 3
The adapter protein Lamellipodin (Lpd) plays an important role in cell migration. In particular, Lpd mediates lamellipodia formation by regulating actin dynamics via interacting with Ena/VASP proteins. Its RA-PH tandem domain configuration suggests that like its paralog RIAM, Lpd may also mediate particular Ras GTPase signaling. We determined the crystal structures of the Lpd RA-PH domains alone and with an N-terminal coiled-coil region (cc-RA-PH). These structures reveal that apart from the ant ...[more]