Ontology highlight
ABSTRACT:
SUBMITTER: Hastings AK
PROVIDER: S-EPMC4875773 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Hastings Andrew K AK Gilchuk Pavlo P Joyce Sebastian S Williams John V JV
Vaccine 20160419 24
Human metapneumovirus (HMPV) is a major cause of morbidity and mortality from acute lower respiratory tract illness, with most individuals seropositive by age five. Despite the presence of neutralizing antibodies, secondary infections are common and can be severe in young, elderly, and immunocompromised persons. Preclinical vaccine studies for HMPV have suggested a need for a balanced antibody and T cell immune response to enhance protection and avoid lung immunopathology. We infected transgenic ...[more]