Ontology highlight
ABSTRACT:
SUBMITTER: Gu R
PROVIDER: S-EPMC4875846 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Gu Rende R Brown Rogers M RM Hsu Chih-Wei CW Cai Tiantian T Crowder Alyssa L AL Piazza Victor G VG Vadakkan Tegy J TJ Dickinson Mary E ME Groves Andrew K AK
Developmental biology 20160414 1
The transcription factor Sox2 is both necessary and sufficient for the generation of sensory regions of the inner ear. It regulates expression of the Notch ligand Jag1 in prosensory progenitors, which signal to neighboring cells to up-regulate Sox2 and sustain prosensory identity. However, the expression pattern of Sox2 in the early inner ear is very broad, suggesting that Sox2-expressing progenitors form a wide variety of cell types in addition to generating the sensory regions of the ear. We u ...[more]