Ontology highlight
ABSTRACT:
SUBMITTER: Gubser C
PROVIDER: S-EPMC4876466 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Gubser Céline C Schmaler Mathias M Rossi Simona W SW Palmer Ed E
Scientific reports 20160523
Regulatory T cells (Tregs) have a crucial role in maintaining lymphocyte homeostasis. However an understanding of how Tregs function at a cellular and molecular level has not yet been fully elucidated. Here, we make use of a T cell receptor (TCR) transgenic, Rag(-/-) mouse expressing a Forkhead-Box-Protein P3 (Foxp3) transgene. This mouse provides a source of monoclonal CD4(+) Foxp3(+) T cells with a defined specificity. Here we show that monoclonal B3K506 Tregs are functional in vitro and in vi ...[more]