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Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report.

ABSTRACT: Emerging data suggest that type 1 diabetes is a more aggressive disease in children than in adults, with important differences in pathophysiology and clinical course. Therefore, the efficacy of disease-modifying therapies may be different in the two populations. Understanding the developmental and regulatory pathways for type 1 diabetes-modifying therapies in children will enable industry, academia, funders, advocacy groups, and regulators to translate new science to clinical care. This consensus report characterizes the fundamental differences in type 1 diabetes between children and adults and proposes a thoughtful approach to better understand the development and regulatory pathways for type 1 diabetes therapies.

SUBMITTER: Wherrett DK

PROVIDER: S-EPMC4876737 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report.

Wherrett Diane K DK Chiang Jane L JL Delamater Alan M AM DiMeglio Linda A LA Gitelman Stephen E SE Gottlieb Peter A PA Herold Kevan C KC Lovell Daniel J DJ Orchard Trevor J TJ Ryan Christopher M CM Schatz Desmond A DA Wendler David S DS Greenbaum Carla J CJ

Diabetes care 20151001 10

Emerging data suggest that type 1 diabetes is a more aggressive disease in children than in adults, with important differences in pathophysiology and clinical course. Therefore, the efficacy of disease-modifying therapies may be different in the two populations. Understanding the developmental and regulatory pathways for type 1 diabetes-modifying therapies in children will enable industry, academia, funders, advocacy groups, and regulators to translate new science to clinical care. This consensu ...[more]

PMID: 26404927

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