Uncovering Pathways to Personalized Therapies in Type 1 Diabetes.

ABSTRACT: The goal of personalized medicine is to match the right drugs to the right patients at the right time. Personalized medicine has been most successful in cases where there is a clear genetic linkage between a disease and a therapy. This is not the case with type 1 diabetes (T1D), a genetically complex immune-mediated disease of β-cell destruction. Researchers over decades have traced the natural history of disease sufficiently to use autoantibodies as predictive biomarkers for disease risk and to conduct successful clinical trials of disease-modifying therapy. Recent studies, however, have highlighted heterogeneity associated with progression, with nonuniform rate of insulin loss and distinct features of the peri-diagnostic period. Likewise, there is heterogeneity in immune profiles and out

SUBMITTER: Linsley PS 

PROVIDER: S-EPMC7980192 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature