Ontology highlight
ABSTRACT:
SUBMITTER: Yang NJ
PROVIDER: S-EPMC4876977 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Yang Nicole J NJ Liu David V DV Sklaviadis Demetra D Gui Dan Y DY Vander Heiden Matthew G MG Wittrup K Dane KD
Molecular pharmaceutics 20150504 6
Perfringolysin O (PFO) is a member of the cholesterol-dependent cytolysin (CDC) family of bacterial pore-forming proteins, which are highly efficient in delivering exogenous proteins to the cytoplasm. However, the indiscriminate and potent cytotoxicity of PFO limits its practical use as an intracellular delivery system. In this study, we describe the design and engineering of a bispecific, neutralizing antibody against PFO, which targets reversibly attenuated PFO to endocytic compartments via re ...[more]