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Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.

ABSTRACT: A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at ?=5.0?ppm before enzyme activity, and a second CEST signal appears at ?=9.0?ppm after the enzyme cleaves a sulfate group from the agent. The comparison of the two signals improved detection of sulfatase activity.

SUBMITTER: Sinharay S 

PROVIDER: S-EPMC4877021 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.

Sinharay Sanhita S   Fernández-Cuervo Gabriela G   Acfalle Jasmine P JP   Pagel Mark D MD  

Chemistry (Weinheim an der Bergstrasse, Germany) 20160323 19

A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at δ=5.0 ppm before enzyme activity, and a second CEST signal appears at δ=9.0 ppm after the enzyme cleaves a sulfate group from the agent. The comparison of the two signals improved detection of sulfatase activity. ...[more]

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