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Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent.

ABSTRACT: A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.

SUBMITTER: Daryaei I 

PROVIDER: S-EPMC6010184 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent.

Daryaei Iman I   Jones Kyle M KM   Pagel Mark D MD  

Chemistry (Weinheim an der Bergstrasse, Germany) 20170420 27

A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme. ...[more]

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