Quantitative Proteomics Analysis of Tissue Interstitial Fluid for Identification of Novel Serum Candidate Diagnostic Marker for Hepatocellular Carcinoma.
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ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC4877711 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Quantitative Proteomics Analysis of Tissue Interstitial Fluid for Identification of Novel Serum Candidate Diagnostic Marker for Hepatocellular Carcinoma.
Sun Wei W Xing Baocai B Guo Lihai L Liu Zhilei Z Mu Jinsong J Sun Longqin L Wei Handong H Zhao Xiaohang X Qian Xiaohong X Jiang Ying Y He Fuchu F
Scientific reports 20160524
Hepatocellular carcinoma (HCC) is the fifth most common malignant cancer in the world. The sensitivity of alpha-fetoprotein (AFP) is still inadequate for HCC diagnosis. Tissue interstitial fluid (TIF), as the liquid microenvironment of cancer cells, was used for biomarker discovery in this study. Paired tumor and nontumor TIF samples from 6 HBV-HCC patients were analyzed by a proteomic technique named iTRAQ (isobaric tag for relative and absolute quantitation). Totally, 241 up-regulated proteins ...[more]
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