CYP2C19 drug-drug and drug-gene interactions in ED patients.

ABSTRACT:

Background

CYP450 polymorphisms result in variable rates of drug metabolism. CYP drug-drug interactions can contribute to altered drug effectiveness and safety.

Study objectives

The primary objective was to determine the percentage of emergency department (ED) patients with cytochrome 2C19 (CYP2C19) drug-drug interactions. The secondary objective was to determine the prevalence of CYP2C19 polymorphisms in a US ED population.

Methods

We conducted a prospective observational study in an urban academic ED with 72,000 annual visits. Drug ingestion histories for the 48 hours preceding ED visit were obtained; each drug was coded as CYP2C19 substrate, inhibitor, inducer, or not CYP2C19 dependent. Ten percent of patients were randomized to undergo CYP2C19 genotyping using the

SUBMITTER: Flaten HK 

PROVIDER: S-EPMC4878122 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature