Ontology highlight
ABSTRACT:
SUBMITTER: Piermattei A
PROVIDER: S-EPMC4878199 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Frontiers in immunology 20160524
Mycobacteria display pro- and anti-inflammatory effects in human and experimental pathology. We show here that both effects are mediated by Toll-like receptor 2 (Tlr2), by exploiting a previously characterized Tlr2 variant (Met82Ile). Tlr2 82ile promoted self-specific proinflammatory polarization as well as expansion of ag-specific FoxP3(+) Tregs, while Tlr2 82met impairs the expansion of Tregs and reduces the production of IFN-γ and IL-17 proinflammatory cytokines. Preferential dimerization wit ...[more]