Ontology highlight
ABSTRACT:
SUBMITTER: Patterson S
PROVIDER: S-EPMC4878867 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Patterson Stephen S Wyllie Susan S Norval Suzanne S Stojanovski Laste L Simeons Frederick Rc FR Auer Jennifer L JL Osuna-Cabello Maria M Read Kevin D KD Fairlamb Alan H AH
eLife 20160524
There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of visceral leishmaniasis (VL). We report that delamanid (OPC-67683), an approved drug for multi-drug resistant tuberculosis, is a potent inhibitor of Leishmania donovani both in vitro and in vivo. Twice-daily oral dosing of delamanid at 30 mg kg(-1) for 5 days resulted in sterile cures in a mouse model of VL. Treatment with lower doses revealed a U-shaped (hormetic) dose-response curve with greater parasite ...[more]