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Role of Antifungal Susceptibility Testing in Non-Aspergillus Invasive Mold Infections.


ABSTRACT: No clinical breakpoints are available to delineate antifungal drug efficacy in non-Aspergillus invasive mold infections (NAIMIs). In this analysis of 39 NAIMI episodes, the MIC of the first-line antifungal drug was the most important predictor of therapeutic response. For amphotericin B, an MIC of ?0.5 ?g/ml was significantly associated with better 6-week outcomes.

SUBMITTER: Lamoth F 

PROVIDER: S-EPMC4879309 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Role of Antifungal Susceptibility Testing in Non-Aspergillus Invasive Mold Infections.

Lamoth Frédéric F   Damonti Lauro L   Alexander Barbara D BD  

Journal of clinical microbiology 20160323 6


No clinical breakpoints are available to delineate antifungal drug efficacy in non-Aspergillus invasive mold infections (NAIMIs). In this analysis of 39 NAIMI episodes, the MIC of the first-line antifungal drug was the most important predictor of therapeutic response. For amphotericin B, an MIC of ≤0.5 μg/ml was significantly associated with better 6-week outcomes. ...[more]

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