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Susceptibility Testing of Common and Uncommon Aspergillus Species against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method.


ABSTRACT: We tested 59 common and 27 uncommon Aspergillus species isolates for susceptibility to the mold-active azole antifungal agents itraconazole, voriconazole, and posaconazole using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole and was 100% for voriconazole. By the Sensititre method as well as the CLSI reference method, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type isolates (MIC > epidemiological cutoff value [ECV]) with respect to triazole susceptibility.

SUBMITTER: Mello E 

PROVIDER: S-EPMC5444134 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Susceptibility Testing of Common and Uncommon Aspergillus Species against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method.

Mello Enrica E   Posteraro Brunella B   Vella Antonietta A   De Carolis Elena E   Torelli Riccardo R   D'Inzeo Tiziana T   Verweij Paul E PE   Sanguinetti Maurizio M  

Antimicrobial agents and chemotherapy 20170524 6


We tested 59 common and 27 uncommon <i>Aspergillus</i> species isolates for susceptibility to the mold-active azole antifungal agents itraconazole, voriconazole, and posaconazole using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole and was 100% for voriconazole. By the Sensititre method as well as the CLSI reference method, all of 10 <i>A. fumigatus</i> isolates with a <i>cyp51</i> mutant genotype were classified  ...[more]

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