Ontology highlight
ABSTRACT:
SUBMITTER: Liang SH
PROVIDER: S-EPMC4879824 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Liang Steven H SH Holland Jason P JP Stephenson Nickeisha A NA Kassenbrock Alina A Rotstein Benjamin H BH Daignault Cory P CP Lewis Rebecca R Collier Lee L Hooker Jacob M JM Vasdev Neil N
ACS chemical neuroscience 20150324 4
Fluorine-18 labeled 2-fluoro-8-hydroxyquinoline ([(18)F]CABS13) is a promising positron emission tomography (PET) radiopharmaceutical based on a metal chelator developed to probe the "metal hypothesis of Alzheimer's disease". Herein, a practical radiosynthesis of [(18)F]CABS13 was achieved by radiofluorination followed by deprotection of an O-benzyloxymethyl group. Automated production and formulation of [(18)F]CABS13 resulted in 19 ± 5% uncorrected radiochemical yield, relative to starting [(18 ...[more]