Ontology highlight
ABSTRACT:
SUBMITTER: Ramanathan B
PROVIDER: S-EPMC4880327 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ramanathan Babu B Poh Chit Laa CL Kirk Kristin K McBride William John Hannan WJ Aaskov John J Grollo Lara L
PloS one 20160525 5
Dengue virus (DENV) is a major public health threat worldwide. A key element in protection from dengue fever is the neutralising antibody response. Anti-dengue IgG purified from DENV-2 infected human sera showed reactivity against several peptides when evaluated by ELISA and epitope extraction techniques. A multi-step computational approach predicted six antigenic regions within the E protein of DENV-2 that concur with the 6 epitopes identified by the combined ELISA and epitope extraction approa ...[more]