Ontology highlight
ABSTRACT:
SUBMITTER: Epps A
PROVIDER: S-EPMC4880406 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
International journal for innovation education and research 20140101 12
Solvent-free reaction using a high-speed ball milling technique has been applied to the classical Ullmann coupling reaction for the first time. Biarylation of 2-iodonitrobenzene was achieved in quantitative yield when performed in a custom-made copper vial through continuous shaking without additional copper or solvent. The product was solid, NMR ready and required no lengthy extraction for purification. This reaction was cleaner, and faster than solution phase coupling which requires longer rea ...[more]