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Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation.

ABSTRACT: 1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a-h and glycine alkyl esters 2a-c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa-ea in good yields. The γ-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin, and kidney cancer cells.

SUBMITTER: Dudhe P

PROVIDER: S-EPMC8218543 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues.

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