Ontology highlight
ABSTRACT:
SUBMITTER: Hanson RL
PROVIDER: S-EPMC4880492 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Hanson Robert L RL Leti Fatjon F Tsinajinnie Darwin D Kobes Sayuko S Puppala Sobha S Curran Joanne E JE Almasy Laura L Lehman Donna M DM Blangero John J Duggirala Ravindranath R DiStefano Johanna K JK
Molecular genetics and metabolism 20160419 2
We previously identified a locus linked to total cholesterol (TC) concentration in Pima Indians on chromosome 19p. To characterize this locus, we genotyped >2000 SNPs in 1838 Pimas and assessed association with log(TC). We observed evidence for association with log(TC) with rs2278426 (3.5% decrease/copy of the T allele; P=5.045×10(-6)) in the ANGPTL8 (angiopoietin-like 8) gene. We replicated this association in 2413 participants of the San Antonio Mexican American Family Study (SAMAFS: 2.0% decr ...[more]