Ontology highlight
ABSTRACT:
SUBMITTER: Haller JF
PROVIDER: S-EPMC5454515 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Haller Jorge F JF Mintah Ivory J IJ Shihanian Lisa M LM Stevis Panayiotis P Buckler David D Alexa-Braun Corey A CA Kleiner Sandra S Banfi Serena S Cohen Jonathan C JC Hobbs Helen H HH Yancopoulos George D GD Murphy Andrew J AJ Gusarova Viktoria V Gromada Jesper J
Journal of lipid research 20170415 6
Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL proteins interact to regulate LPL activity. ANGPTL3 inhibits LPL activity and increases serum TG independent of ANGPTL8. These effects are reversed with an ANGPTL3 blocking antibody. Here, we show that ANGPTL8, although it possesses a functional inhibitory motif, is inactive by itself and requires ANGPTL3 expression to inhibit LPL and ...[more]