Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle.
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ABSTRACT:
SUBMITTER: Vandanmagsar B
PROVIDER: S-EPMC4880522 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle.
Vandanmagsar Bolormaa B Warfel Jaycob D JD Wicks Shawna E SE Ghosh Sujoy S Salbaum J Michael JM Burk David D Dubuisson Olga S OS Mendoza Tamra M TM Zhang Jingying J Noland Robert C RC Mynatt Randall L RL
Cell reports 20160512 8
Fatty acids are the primary fuel source for skeletal muscle during most of our daily activities, and impaired fatty acid oxidation (FAO) is associated with insulin resistance. We have developed a mouse model of impaired FAO by deleting carnitine palmitoyltransferase-1b specifically in skeletal muscle (Cpt1b(m-/-)). Cpt1b(m-/-) mice have increased glucose utilization and are resistant to diet-induced obesity. Here, we show that inhibition of mitochondrial FAO induces FGF21 expression specifically ...[more]
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