Ontology highlight
ABSTRACT:
SUBMITTER: Wicks SE
PROVIDER: S-EPMC4485116 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Wicks Shawna E SE Vandanmagsar Bolormaa B Haynie Kimberly R KR Fuller Scott E SE Warfel Jaycob D JD Stephens Jacqueline M JM Wang Miao M Han Xianlin X Zhang Jingying J Noland Robert C RC Mynatt Randall L RL
Proceedings of the National Academy of Sciences of the United States of America 20150608 25
The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxidation (FAO), and insulin resistance have led to the hypothesis that impaired FAO causes accumulation of lipotoxic intermediates that inhibit muscle insulin signaling. Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO model, we show that prolonged and severe mitochondrial FAO inhibition results in increased carbohydrate utilization, along with reduced physical activity; increased circulating nonest ...[more]