TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells.
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ABSTRACT:
SUBMITTER: Huang YK
PROVIDER: S-EPMC4881487 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells.
Huang Yu-Kun YK Fan Xue-Gong XG Qiu Fu F
International journal of molecular sciences 20160503 5
Transmembrane 4 superfamily member 1 (TM4SF1) is a member of tetraspanin family, which mediates signal transduction events regulating cell development, activation, growth and motility. Our previous studies showed that TM4SF1 is highly expressed in liver cancer. HepG2 cells were transfected with TM4SFl siRNA and TM4SF1-expressing plasmids and their biological functions were analyzed in vitro and in vivo. HepG2 cells overexpressing TM4SF1 showed reduced apoptosis and increased cell migration in vi ...[more]
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