Ontology highlight
ABSTRACT:
SUBMITTER: Yang JC
PROVIDER: S-EPMC5377454 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Yang Jia-Chun JC Zhang Yi Y He Si-Jia SJ Li Ming-Ming MM Cai Xiao-Lei XL Wang Hui H Xu Lei-Ming LM Cao Jia J
Scientific reports 20170403
Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. However, the TM4SF1-associated signaling network in metastasis remains unknown. In the present study, we found that TM4SF1 affected the formation and function of invadopodia. Silencing of TM4SF1 reduced the expression of DDR1 significantly in PANC-1 and AsPC-1 cells. Through double fluorescence immuno-staining and Co-immu ...[more]