Ontology highlight
ABSTRACT:
SUBMITTER: McNally R
PROVIDER: S-EPMC4881981 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
McNally Randall R Toms Angela V AV Eck Michael J MJ
PloS one 20160526 5
Jak-family tyrosine kinases mediate signaling from diverse cytokine receptors. Binding of Jaks to their cognate receptors is mediated by their N-terminal region, which contains FERM and SH2 domains. Here we describe the crystal structure of the FERM-SH2 region of Jak2 at 3.0Å resolution. The structure reveals that these domains and their flanking linker segments interact intimately to form an integrated structural module. The Jak2 FERM-SH2 structure closely resembles that recently described for ...[more]