Ontology highlight
ABSTRACT:
SUBMITTER: Hsu PL
PROVIDER: S-EPMC6108940 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Hsu Peter L PL Li Heng H Lau Ho-Tak HT Leonen Calvin C Dhall Abhinav A Ong Shao-En SE Chatterjee Champak C Zheng Ning N
Cell 20180809 5
The SET1/MLL family of histone methyltransferases is conserved in eukaryotes and regulates transcription by catalyzing histone H3K4 mono-, di-, and tri-methylation. These enzymes form a common five-subunit catalytic core whose assembly is critical for their basal and regulated enzymatic activities through unknown mechanisms. Here, we present the crystal structure of the intact yeast COMPASS histone methyltransferase catalytic module consisting of Swd1, Swd3, Bre2, Sdc1, and Set1. The complex is ...[more]