Ontology highlight
ABSTRACT:
SUBMITTER: Savage LJ
PROVIDER: S-EPMC4883251 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Savage Laura J LJ Wittmann Miriam M McGonagle Dennis D Helliwell Philip S PS
Rheumatology and therapy 20150317 1
Biologics have revolutionized the therapy of the psoriatic disease spectrum. These new classes of drugs also allow deeper insight into the pathogenesis of the disease and highlight the existence of distinct "molecular" disease subgroups as evidenced by the spectrum of clinical response seen. Molecules associated with both the interleukin (IL)-17 and interferon (IFN)γ pathways have important functions in psoriatic inflammation, and both are targeted by drugs acting on the p40 subunit shared by IL ...[more]