Dataset Information

Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging.

ABSTRACT: To investigate the relationship between vestibular loss associated with aging and age-related decline in visuospatial function.Cross-sectional analysis within a prospective cohort study.Baltimore Longitudinal Study of Aging (BLSA).Community-dwelling BLSA participants with a mean age of 72 (range 26-91) (N = 183).Vestibular function was measured using vestibular-evoked myogenic potentials. Visuospatial cognitive tests included Card Rotations, Purdue Pegboard, Benton Visual Retention Test, and Trail-Making Test Parts A and B. Tests of executive function, memory, and attention were also considered.Participants underwent vestibular and cognitive function testing. In multiple linear regression analyses, poorer vestibular function was associated with poorer performance on Card Rotations (P = .001), Purdue Pegboard (P = .005), Benton Visual Retention Test (P = 0.008), and Trail-Making Test Part B (P = .04). Performance on tests of executive function and verbal memory were not significantly associated with vestibular function. Exploratory factor analyses in a subgroup of participants who underwent all cognitive tests identified three latent cognitive abilities: visuospatial ability, verbal memory, and working memory and attention. Vestibular loss was significantly associated with lower visuospatial and working memory and attention factor scores.Significant consistent associations between vestibular function and tests of visuospatial ability were observed in a sample of community-dwelling adults. Impairment in visuospatial skills is often one of the first signs of dementia and Alzheimer's disease. Further longitudinal studies are needed to evaluate whether the relationship between vestibular function and visuospatial ability is causal.

SUBMITTER: Bigelow RT

PROVIDER: S-EPMC4883683 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging.

Bigelow Robin T RT Semenov Yevgeniy R YR Trevino Carolina C Ferrucci Luigi L Resnick Susan M SM Simonsick Eleanor M EM Xue Qian-Li QL Agrawal Yuri Y

Journal of the American Geriatrics Society 20150827 9

<h4>Objectives</h4>To investigate the relationship between vestibular loss associated with aging and age-related decline in visuospatial function.<h4>Design</h4>Cross-sectional analysis within a prospective cohort study.<h4>Setting</h4>Baltimore Longitudinal Study of Aging (BLSA).<h4>Participants</h4>Community-dwelling BLSA participants with a mean age of 72 (range 26-91) (N = 183).<h4>Measurements</h4>Vestibular function was measured using vestibular-evoked myogenic potentials. Visuospatial cog ...[more]

PMID: 26311169

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Project description:ImportanceBlood biomarkers able to diagnose Alzheimer disease (AD) at the preclinical stage would enable trial enrollment when the disease is potentially reversible. Plasma neuronal-enriched extracellular vesicles (nEVs) of patients with AD were reported to exhibit elevated levels of phosphorylated (p) tau, Aβ42, and phosphorylated insulin receptor substrate 1 (IRS-1).ObjectiveTo validate nEV biomarkers as AD predictors.Design, setting, participantsThis case-control study included longitudinal plasma samples from cognitively normal participants in the Baltimore Longitudinal Study of Aging (BLSA) cohort who developed AD up to January 2015 and age- and sex-matched controls who remained cognitively normal over a similar length of follow-up. Repeated samples were blindly analyzed over 1 year from participants with clinical AD and controls from the Johns Hopkins Alzheimer Disease Research Center (JHADRC). Data were collected from September 2016 to January 2018. Analyses were conducted in March 2019.Main outcomes and measuresNeuronal-enriched extracellular vesicles were immunoprecipitated; tau, Aβ42, and IRS-1 biomarkers were quantified by immunoassays; and nEV concentration and diameter were determined by nanoparticle tracking analysis. Levels and longitudinal trajectories of nEV biomarkers between participants with future AD and control participants were compared.ResultsOverall, 887 longitudinal plasma samples from 128 BLSA participants who eventually developed AD and 222 age and sex-matched controls who remained cognitively normal were analyzed. Participants were followed up (from earliest sample to AD symptom onset) for a mean (SD) of 3.5 (2.31) years (range, 0-9.73 years). Overall, 161 participants were included in the training set, and 80 were in the test set. Participants in the BLSA cohort with future AD (mean [SD] age, 79.09 [7.02] years; 68 women [53.13%]) had longitudinally higher p-tau181, p-tau231, pSer312-IRS-1, pY-IRS-1, and nEV diameter than controls (mean [SD] age, 76.2 [7.36] years; 110 women [50.45%]) but had similar Aβ42, total tau, TSG101, and nEV concentration. In the training BLSA set, a model combining preclinical longitudinal data achieved 89.6% area under curve (AUC), 81.8% sensitivity, and 85.8% specificity for predicting AD. The model was validated in the test BLSA set (80% AUC, 55.6% sensitivity, 88.7% specificity). Preclinical levels of nEV biomarkers were associated with cognitive performance. In addition, 128 repeated samples over 1 year from 64 JHADRC participants with clinical AD and controls were analyzed. In the JHADRC cohort (35 participants with AD: mean [SD] age, 74.03 [8.73] years; 18 women [51.43%] and 29 controls: mean [SD] age, 72.14 [7.86] years; 23 women [79.31%]), nEV biomarkers achieved discrimination with 98.9% AUC, 100% sensitivity, and 94.7% specificity in the training set and 76.7% AUC, 91.7% sensitivity, and 60% specificity in the test set.Conclusions and relevanceWe validated nEV biomarker candidates and further demonstrated that their preclinical longitudinal trajectories can predict AD diagnosis. These findings motivate further development of nEV biomarkers toward a clinical blood test for AD.

Dataset Information

Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging.

Publications

Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging.

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