Dataset Information

Vestibular Function and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging.

ABSTRACT: Beta-amyloid (A?) plaque deposition is a key feature of Alzheimer's disease (AD), and occurs years before the onset of symptoms. A? plaque deposition has been shown to be present in ~30% of cognitively normal older adults using amyloid C-11 labeled Pittsburgh Compound B (¹¹C-PiB) Positron Emission Tomography (PET) imaging. Prior studies have reported a link between reduced vestibular function and poorer cognition in healthy older adults. It is unknown whether vestibular impairment occurs in association with AD pathology among individuals in the preclinical phase of AD, which could contribute to the observed association between vestibular and cognitive function in healthy older adults. Using the Baltimore Longitudinal Study of Aging (BLSA), we analyzed the association between a comprehensive set of vestibular function measures and PiB status in 98 healthy participants with a mean age of 77.3 (±8.26). We did not observe a significant relationship between any vestibular function measure and PiB status in cognitively-intact older adults in the BLSA. This finding suggests that A? deposition does not explain the observed association between reduced vestibular function and poorer cognition in healthy older adults.

SUBMITTER: Kamil RJ

PROVIDER: S-EPMC6297212 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Vestibular Function and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging.

Kamil Rebecca J RJ Bilgel Murat M Wong Dean F DF Resnick Susan M SM Agrawal Yuri Y

Frontiers in aging neuroscience 20181211

Beta-amyloid (Aβ) plaque deposition is a key feature of Alzheimer's disease (AD), and occurs years before the onset of symptoms. Aβ plaque deposition has been shown to be present in ~30% of cognitively normal older adults using amyloid C-11 labeled Pittsburgh Compound B (<sup>11</sup>C-PiB) Positron Emission Tomography (PET) imaging. Prior studies have reported a link between reduced vestibular function and poorer cognition in healthy older adults. It is unknown whether vestibular impairment occ ...[more]

PMID: 30618715

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Project description:Background and objectivesPet ownership or human-animal interaction has been associated with better health outcomes in individuals with disease or disability. We hypothesized that pet ownership, as well as dog ownership and cat ownership separately, are associated with maintaining physical function, and leisure time physical activity and that among dog owners, dog walking is associated with maintaining these outcomes for generally healthy community-dwelling older adults participating in the Baltimore Longitudinal Study of Aging.Research design and methodsA total of 637 men (44.1%) and women aged 50-100 years (M = 68.3, standard deviation [SD] = 9.6) completed a comprehensive pet ownership questionnaire that ascertained pet ownership history 10-13 years and had serial assessments of physical function every 1-4 years prior. Linear or generalized linear mixed models with time varying pet ownership were used to examine change in physical function over a mean of 7.5 years (range 1-13, SD = 3.6) according to pet ownership.ResultsPet owners (n = 185) were significantly younger (p < .001) and had fewer comorbidities (p = .03) than nonowners; thus, age and comorbidities were included as covariates in the longitudinal analyses. Physical function and leisure time physical activity declined with aging across all outcomes (p < .001); the decline was slower among pet owners in overall physical performance (p < .001), rapid gait speed (p = .03), usual gait speed (p = .032), cardiorespiratory fitness (p < .001), and physical well-being (p = .002) controlling for age and comorbidities. Changes in leisure time physical activities with aging did not differ between pet owners and nonowners. Dog walking was not independently related to the maintenance of physical function or leisure time physical activity with aging.Discussion and implicationsThis study provides the first longitudinal evidence that pet ownership is associated with maintained physical function among community-dwelling generally healthy older adults.

Dataset Information

Vestibular Function and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging.

Publications

Vestibular Function and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging.

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