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Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.

ABSTRACT: Bioassay- and LC-MS-guided fractionation of a methanol extract from a new deep-water Alaskan sponge species of the genus Latrunculia resulted in the isolation of two new brominated pyrroloiminoquinones, dihydrodiscorhabdin B and discorhabdin Y (2), along with six known pyrroloiminoquinone alkaloids, discorhabdins A (3), C (4), E (5), and L (6), dihydrodiscorhabdin C (7), and the benzene derivative 8. Compounds 3, 4, and 7 exhibited anti-HCV activity, antimalarial activity, and selective antimicrobial activity. Although compounds 3 and 7 displayed potent and selective in vitro antiprotozoal activity, Plasmodium berghei-infected mice did not respond to these metabolites due to their toxicity in vivo.

SUBMITTER: Na M

PROVIDER: S-EPMC4883701 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.

Na Minkyun M Ding Yuanqing Y Wang Bin B Tekwani Babu L BL Schinazi Raymond F RF Franzblau Scott S Kelly Michelle M Stone Robert R Li Xing-Cong XC Ferreira Daneel D Hamann Mark T MT

Journal of natural products 20100301 3

Bioassay- and LC-MS-guided fractionation of a methanol extract from a new deep-water Alaskan sponge species of the genus Latrunculia resulted in the isolation of two new brominated pyrroloiminoquinones, dihydrodiscorhabdin B and discorhabdin Y (2), along with six known pyrroloiminoquinone alkaloids, discorhabdins A (3), C (4), E (5), and L (6), dihydrodiscorhabdin C (7), and the benzene derivative 8. Compounds 3, 4, and 7 exhibited anti-HCV activity, antimalarial activity, and selective antimicr ...[more]

PMID: 20337497

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