Sensitive detection and glycoprofiling of a prostate specific antigen using impedimetric assays.
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ABSTRACT:
SUBMITTER: Pihikova D
PROVIDER: S-EPMC4884444 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Sensitive detection and glycoprofiling of a prostate specific antigen using impedimetric assays.
Pihíková D D Belicky Š Š Kasák P P Bertok T T Tkac J J
The Analyst 20151209 3
This study presents a proof-of-concept for the development of an impedimetric biosensor for ultra-sensitive glycoprofiling of prostate specific antigen (PSA). The biosensor exhibits three unique characteristics: (1) analysis of PSA with limit of detection (LOD) down to 4 aM; (2) analysis of the glycan part of PSA with LOD down to 4 aM level and; (3) both assays (i.e., PSA quantification and PSA glycoprofiling) can be performed on the same interface due to label-free analysis. ...[more]
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