Ontology highlight
ABSTRACT:
SUBMITTER: Hnisz D
PROVIDER: S-EPMC4884612 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160303 6280
Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we investigated whether proto-oncogenes occur within these structures and whether oncogene activation can occur via disruption of insulated neighborhood boundaries in cancer cells. We mapped insulated neighborhoods in T cell acute lymphoblastic leuk ...[more]