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Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging.

ABSTRACT: Nanoprobes for MRI and optical imaging are demonstrated. Gd@C-dots possess strong fluorescence and can effectively enhance signals on T1 -weighted MR images. The nanoprobes have low toxicity, and, despite a relatively large size, can be efficiently excreted by renal clearance from the host after systemic injection.

SUBMITTER: Chen H 

PROVIDER: S-EPMC4885638 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging.

Chen Hongmin H   Wang Geoffrey D GD   Tang Wei W   Todd Trever T   Zhen Zipeng Z   Tsang Chu C   Hekmatyar Khan K   Cowger Taku T   Hubbard Richard R   Zhang Weizhong W   Stickney John J   Shen Baozhong B   Xie Jin J  

Advanced materials (Deerfield Beach, Fla.) 20140901 39

Nanoprobes for MRI and optical imaging are demonstrated. Gd@C-dots possess strong fluorescence and can effectively enhance signals on T1 -weighted MR images. The nanoprobes have low toxicity, and, despite a relatively large size, can be efficiently excreted by renal clearance from the host after systemic injection. ...[more]

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