Linear PVA-DTPA-Gd conjugate for magnetic resonance imaging.
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ABSTRACT:
SUBMITTER: Xu W
PROVIDER: S-EPMC9075117 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Linear PVA-DTPA-Gd conjugate for magnetic resonance imaging.
Xu Weibing W Lin Zhiyan Z Li Guichen G Long Haitao H Du Mingyuan M Fu Guorui G Pu Lumei L
RSC advances 20191112 63
In this study, we report the preparation and characterization of the PVA-DTPA-Gd conjugate as a potential MRI contrast agent (CA). The <i>r</i> <sub>1</sub> value and the <i>r</i> <sub>2</sub>/<i>r</i> <sub>1</sub> ratio were about 5.6 mM<sup>-1</sup> s<sup>-1</sup> and 1.31, respectively. <i>In vitro</i> toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA. ...[more]
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