Ontology highlight
ABSTRACT:
SUBMITTER: Shim JW
PROVIDER: S-EPMC4886677 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Shim Joon W JW Sandlund Johanna J Hameed Mustafa Q MQ Blazer-Yost Bonnie B Zhou Feng C FC Klagsbrun Michael M Madsen Joseph R JR
Scientific reports 20160531
Heparin binding epidermal growth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the developing forebrain, while vascular endothelial growth factor (VEGF) is known to influence rostral migratory stream in rodents. Cell migratory defects have been identified in animal models of hydrocephalus; however, the relationship between HB-EGF and hydrocephalus is unclear. We show that mice overexpressing human HB-EGF with β-galactosidase reporter exhibit an elevated ...[more]